武漢多普樂生物醫(yī)藥有限公司
武漢市洪山區(qū)獅子山北路攬勝匯公寓樓1號樓B區(qū)619室
錢小如
19945035818 027-87215551
2881924056
2881924056@qq.com
CAS 679818-59-8 分子量 149000.00 靶點： CD20; Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation
Ofatumumab is a humanised anti-CD20 monoclonal antibody whose epitope is distinct from that of rituximab. The CD20 antigen is expressed on solely B cell lymphocytes. Compared with rituximab, ofatumumab binds more tightly to CD20 with a slower off-rate. Ofatumumab causes cytotoxicity in the cells that express CD20 by means of complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC).
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 倉鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 體表面積 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km 系數(shù) | 3 | 6 | 12 | 8 | 5 | 20 |
| 動物 A (mg/kg) = 動物 B (mg/kg) × | 動物 B的Km系數(shù) |
| 動物 A的Km系數(shù) |
例如，依據(jù)體表面積折算法，將白藜蘆醇用于小鼠的劑量22.4 mg/kg 換算成大鼠的劑量，需要將22.4 mg/kg 乘以小鼠的Km系數(shù)（3），再除以大鼠的Km系數(shù)（6），得到白藜蘆醇用于大鼠的等效劑量為11.2 mg/kg。
| 分子量 | 146059.83 |
| 分子式 | C6480H10022N1742O2020S44 |
| CAS號 | 679818-59-8 |
| 純度 | >98% |
| 溶解性（25°C） | |
| 儲存和運輸條件 | -80°C for long term 常溫運輸及臨時存放 |
以下數(shù)據(jù)基于產(chǎn)品分子量，對于特殊產(chǎn)品，請參照COA中的儲備液配制條件和說明進行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.0068 mL | 0.0342 mL | 0.0685 mL |
| 5 mM | 0.0014 mL | 0.0068 mL | 0.0137 mL |
| 10 mM | 0.0007 mL | 0.0034 mL | 0.0068 mL |
Ofatumumab: a novel monoclonal anti-CD20 antibody.
Lin TS, et al. Pharmgenomics Pers Med. 2010;3:51-9. PMID: 23226042.
Ofatumumab.
Zhang B, et al. MAbs. 2009 Jul-Aug;1(4):326-31. PMID: 20068404.